Neurodegenerative diseases by studying proteins in the brain to prevent
Researchers report in the October 2007ausgabe of molecular and cellular Proteomics the most complete list so far of the proteins in the cerebral cortex, the outermost layer of the brain are available, which plays a key role in memory, in language, in the recognition and awareness plays . The cerebral cortex is the part of the brain that the stamp contains many neurodegenerative diseases, so these results could help to understand how such diseases develop and possibly find ways to make it slow.
Most neurodegenerative diseases develop in specific regions of the brain. For example occur due to loss of neurons (AD) Alzheimer’s disease mostly in the cerebral cortex and hippo Kamp, and degeneration of neurons in Parkinson’s disease is centered on a large area in the back of the brain, the Brainstem at least in the early stages of the disease is called.
Jing Zhang and colleagues who are over 800 different proteins in a part of the cortex near the forehead identifizierent been appointed the frontal cortex. This region of the brain in many neurodegenerative diseases involved in intellectual function over time, including AD, Parkinson’s disease with dementia (PDD) is deteriorating, and in dementia of Lewy body disease (DLB) and frontotemporal Lobardegeneration (FTLD ).
The proteins used in this study identifizierent will take different roles within the cell, such as the transport of other proteins, the activation of neighboring proteins and the catalysis of biochemical reactions true. Among these proteins, the scientists found that at least half a dozen well-known, with neurodegenerative diseases to be associated, however, the role of other proteins on testing may show that some of them even in these diseases to be included.
The scientists also found that 17 percent of identifizierenten proteins in the cerebrospinal fluid (CSF) an aqueous liquid are present, the brain and the spinal cord surrounds and protects. Since proteins in the CSF than clinically in the cortex are more accessible, could understand how the proteins in the frontal cortex and in CSF are present in neurodegenerative diseases to be included, help to improve their diagnosis and determine disease development.
Taken together, deliver the proteins in this study identifizierent be important information to ultimately understand how the frontal cortex works and what is wrong in many neurodegenerative diseases, the researchers conclude. Zhang and his team are trying now, the most comprehensive list of all the proteins observed in other brain regions, such as the middle-brain work, the difficulty in movement disorders such as Parkinson’s disease is involved.
Article: “Proteomics Identification of proteins in the human cortex using multidimensional separations and MALDI tandem mass spectrometer of,” by Sheng Pan, minimal Shi, Jinghua Jin, Roger L. Albin, Andy Lieberman, Marla gearbox, Biaoyang Lin, Catherine-tub, Xiaowei Yan, Daniel T. Kashima and Jing Zhang
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